Diffusion‐weighted imaging in multiple system atrophy: A comparison between clinical subtypes
Identifieur interne : 000B14 ( Main/Exploration ); précédent : 000B13; suivant : 000B15Diffusion‐weighted imaging in multiple system atrophy: A comparison between clinical subtypes
Auteurs : Maria Teresa Pellecchia [Italie] ; Paolo Barone [Italie] ; Carmine Mollica [Italie] ; Elena Salvatore [Italie] ; Marta Ianniciello [Italie] ; Katia Longo [Italie] ; Andrea Varrone [Italie] ; Caterina Vicidomini [Italie] ; Marina Picillo [Italie] ; Giuseppe De Michele [Italie] ; Alessandro Filla [Italie] ; Marco Salvatore [Italie] ; Sabina Pappatà [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
English descriptors
Abstract
Multiple system atrophy can be classified into two main types, a Parkinsonian (MSA‐P) and a cerebellar (MSA‐C) variant based on clinical presentation. We obtained diffusion‐weighted magnetic resonance imaging (DWI) in 9 MSA‐P and 12 MSA‐C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA‐P than in MSA‐C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA‐C than in MSA‐P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA‐P patients, and in cerebellum and MCP of MSA‐C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA‐P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA‐P and MSA‐C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurodegeneration in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA‐P patients and in the cerebellum and MCP in MSA‐C patients could serve as quantitative markers for microstructural damage in the course of disease. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22440
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffusion‐weighted imaging in multiple system atrophy: A comparison between clinical subtypes</title><author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author><author><name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name></author><author><name sortKey="Ianniciello, Marta" sort="Ianniciello, Marta" uniqKey="Ianniciello M" first="Marta" last="Ianniciello">Marta Ianniciello</name></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name></author><author><name sortKey="Varrone, Andrea" sort="Varrone, Andrea" uniqKey="Varrone A" first="Andrea" last="Varrone">Andrea Varrone</name></author><author><name sortKey="Vicidomini, Caterina" sort="Vicidomini, Caterina" uniqKey="Vicidomini C" first="Caterina" last="Vicidomini">Caterina Vicidomini</name></author><author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name></author><author><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name></author><author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappatà">Sabina Pappatà</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9C2467DD40413763671EA31CD67CBF09EE8A5AD8</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22440</idno><idno type="url">https://api.istex.fr/document/9C2467DD40413763671EA31CD67CBF09EE8A5AD8/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001860</idno><idno type="wicri:Area/Main/Curation">001614</idno><idno type="wicri:Area/Main/Exploration">000B14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Diffusion‐weighted imaging in multiple system atrophy: A comparison between clinical subtypes</title><author><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Fondazione SDN, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Ianniciello, Marta" sort="Ianniciello, Marta" uniqKey="Ianniciello M" first="Marta" last="Ianniciello">Marta Ianniciello</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Varrone, Andrea" sort="Varrone, Andrea" uniqKey="Varrone A" first="Andrea" last="Varrone">Andrea Varrone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Vicidomini, Caterina" sort="Vicidomini, Caterina" uniqKey="Vicidomini C" first="Caterina" last="Vicidomini">Caterina Vicidomini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappatà">Sabina Pappatà</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biostructure and Bioimaging, CNR, Department of Biomorphological Sciences, University Federico II, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-15">2009-04-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="689">689</biblScope><biblScope unit="page" to="696">696</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9C2467DD40413763671EA31CD67CBF09EE8A5AD8</idno><idno type="DOI">10.1002/mds.22440</idno><idno type="ArticleID">MDS22440</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MSA subtypes</term><term>diffusion‐weighted imaging</term><term>magnetic resonance imaging</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Multiple system atrophy can be classified into two main types, a Parkinsonian (MSA‐P) and a cerebellar (MSA‐C) variant based on clinical presentation. We obtained diffusion‐weighted magnetic resonance imaging (DWI) in 9 MSA‐P and 12 MSA‐C patients and 11 controls, and correlated DWI changes with disease duration and severity. We found that Trace (D) values in the entire and anterior putamen were significantly higher in MSA‐P than in MSA‐C patients and controls, whereas Trace (D) values in the cerebellum and middle cerebellar peduncle (MCP) were significantly higher in MSA‐C than in MSA‐P patients and controls. Increased disease duration was significantly correlated with increased Trace (D) values in pons of MSA‐P patients, and in cerebellum and MCP of MSA‐C patients. Both UMSARS and UPDRS motor scores positively correlated with entire and posterior putaminal Trace (D) values in MSA‐P patients. The diffusivity changes parallel phenotypical and pathologic differences between MSA‐P and MSA‐C patients, suggesting that DWI is a feasible tool for in vivo evaluation of neurodegeneration in MSA. Based on our findings, Trace (D) measurements in the putamen and pons in MSA‐P patients and in the cerebellum and MCP in MSA‐C patients could serve as quantitative markers for microstructural damage in the course of disease. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Pellecchia, Maria Teresa" sort="Pellecchia, Maria Teresa" uniqKey="Pellecchia M" first="Maria Teresa" last="Pellecchia">Maria Teresa Pellecchia</name></noRegion><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><name sortKey="Ianniciello, Marta" sort="Ianniciello, Marta" uniqKey="Ianniciello M" first="Marta" last="Ianniciello">Marta Ianniciello</name><name sortKey="Longo, Katia" sort="Longo, Katia" uniqKey="Longo K" first="Katia" last="Longo">Katia Longo</name><name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name><name sortKey="Mollica, Carmine" sort="Mollica, Carmine" uniqKey="Mollica C" first="Carmine" last="Mollica">Carmine Mollica</name><name sortKey="Pappata, Sabina" sort="Pappata, Sabina" uniqKey="Pappata S" first="Sabina" last="Pappatà">Sabina Pappatà</name><name sortKey="Picillo, Marina" sort="Picillo, Marina" uniqKey="Picillo M" first="Marina" last="Picillo">Marina Picillo</name><name sortKey="Salvatore, Elena" sort="Salvatore, Elena" uniqKey="Salvatore E" first="Elena" last="Salvatore">Elena Salvatore</name><name sortKey="Salvatore, Marco" sort="Salvatore, Marco" uniqKey="Salvatore M" first="Marco" last="Salvatore">Marco Salvatore</name><name sortKey="Varrone, Andrea" sort="Varrone, Andrea" uniqKey="Varrone A" first="Andrea" last="Varrone">Andrea Varrone</name><name sortKey="Vicidomini, Caterina" sort="Vicidomini, Caterina" uniqKey="Vicidomini C" first="Caterina" last="Vicidomini">Caterina Vicidomini</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B14 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B14 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:9C2467DD40413763671EA31CD67CBF09EE8A5AD8
|texte= Diffusion‐weighted imaging in multiple system atrophy: A comparison between clinical subtypes
}}
| This area was generated with Dilib version V0.6.23. |  |